I’m not sure that RAS is fully able to handle large files yet. So the 14Gb file might be the problem since the 1 month runs ok. So to use the water quality you might have to keep the size of the output down.
I’m not familiar with water quality. For the unsteady run, you could break it up into say monthly runs. Write out a restart file and then use the restart file for the initial conditions for the next month. Not sure how that would work with WQ.