Just posting for the potential benefit of anyone who encounters this in future:
I had a project generating this error with a 2D model in 6.4.1
Restarting not just HEC-RAS but the computer did not help. Opening the geometry editor it turned out to be just an error about two computation points being too close together; I’m not sure if I somehow managed to save the geometry in RAS Mapper without being prompted about the error, or just overlooked it.